- Trotula of Salerno (11th Century) - Considered the world’s first gynecologist
- Dorotea Bucca (1360-1436) - The first female professor to be accepted onto the board of the university of Bologna
- Artemisia Lomi Gentileschi (1593-1653) - First great female Italian painter
- Elena Cornaro Piscopia (1646-1684) - The first woman in the world to be officially awarded a university degree
- Maria Gaetana Agnesi (1718-1799) - Wrote the first book discussing both differential and integral calculus
- Virginia Oldoini (1837–1899) - The first active woman politician
- Tina Anselmi (b. 1927) - Italy's first woman cabinet officer
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